mTORC1 Activation Requires DRAM-1 by Facilitating Lysosomal Amino Acid Efflux

Sensing nutrient availability is essential for appropriate cellular growth, and mTORC1 is a major regulator of this process. Mechanisms causing mTORC1 activation are, however, complex and diverse. We report here an additional important step in the activation of mTORC1, which regulates the efflux of...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Beaumatin, Florian, O’Prey, Jim, Barthet, Valentin J.A., Zunino, Barbara, Parvy, Jean-Philippe, Bachmann, Alexis Maximilien, O’Prey, Margaret, Kania, Elżbieta, Gonzalez, Pablo Sierra, Macintosh, Robin, Lao, Laurence Y., Nixon, Colin, Lopez, Jonathan, Long, Jaclyn S., Tait, Stephen W.G., Ryan, Kevin M.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6892261/
https://ncbi.nlm.nih.gov/pubmed/31492633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.07.021
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