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KCC2 expression levels are reduced in post mortem brain tissue of Rett syndrome patients

Rett Syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the Methyl CpG binding protein 2 (MECP2) gene. Deficient K(+)-Cl(—)co-transporter 2 (KCC2) expression is suggested to play a key role in the neurodevelopmental delay in RTT patients’ neuronal networks. KCC2 is a major player...

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Bibliografski detalji
Izdano u:Acta Neuropathol Commun
Glavni autori: Hinz, Lisa, Torrella Barrufet, Joan, Heine, Vivi M.
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6892240/
https://ncbi.nlm.nih.gov/pubmed/31796123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-019-0852-x
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