Dichotomous Role of Plasmin in Regulation of Macrophage Function after Acetaminophen Overdose

Kupffer cells and monocyte-derived macrophages are critical for liver repair after acetaminophen (APAP) overdose. These cells produce promitogenic cytokines and growth factors, and they phagocytose dead cell debris, a process that is critical for resolution of inflammation. The factors that regulate...

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Publicado en:Am J Pathol
Autores principales: Roth, Katherine, Strickland, Jenna, Joshi, Nikita, Deng, Meihong, Kennedy, Rebekah C., Rockwell, Cheryl E., Luyendyk, James P., Billiar, Timothy R., Copple, Bryan L.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Investigative Pathology 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6892227/
https://ncbi.nlm.nih.gov/pubmed/31381887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2019.07.003
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