Fine-Tuning of Hydrophobicity in Amphiphilic Polyaspartamide Derivatives for Rapid and Transient Expression of Messenger RNA Directed Toward Genome Engineering in Brain

[Image: see text] Rapid and transient expression of in vitro transcribed mRNA (IVT mRNA) in target cells is a current major challenge in genome engineering therapy. To improve mRNA delivery efficiency, a series of amphiphilic polyaspartamide derivatives were synthesized to contain various hydrophobi...

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Bibliographic Details
Published in:ACS Cent Sci
Main Authors: Kim, Hyun Jin, Ogura, Satomi, Otabe, Takahiro, Kamegawa, Rimpei, Sato, Moritoshi, Kataoka, Kazunori, Miyata, Kanjiro
Format: Artigo
Language:Inglês
Published: American Chemical Society 2019
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6891845/
https://ncbi.nlm.nih.gov/pubmed/31807688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.9b00843
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