Engineering Hydrophobic Protein–Carbohydrate Interactions to Fine-Tune Monoclonal Antibodies

[Image: see text] Biologically active conformations of the IgG1 Fc homodimer are maintained by multiple hydrophobic interactions between the protein surface and the N-glycan. The Fc glycan modulates biological effector functions, including antibody-dependent cellular cytotoxicity (ADCC) which is med...

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Hauptverfasser: Yu, Xiaojie, Baruah, Kavitha, Harvey, David J., Vasiljevic, Snezana, Alonzi, Dominic S., Song, Byeong-Doo, Higgins, Matthew K., Bowden, Thomas A., Scanlan, Christopher N., Crispin, Max
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2013
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3788586/
https://ncbi.nlm.nih.gov/pubmed/23745692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja4014375
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