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Chemical and Structural Analysis of an Antibody Folding Intermediate Trapped during Glycan Biosynthesis
[Image: see text] Human IgG Fc glycosylation modulates immunological effector functions such as antibody-dependent cellular cytotoxicity and phagocytosis. Engineering of Fc glycans therefore enables fine-tuning of the therapeutic properties of monoclonal antibodies. The N-linked glycans of Fc are ty...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical Society
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3593610/ https://ncbi.nlm.nih.gov/pubmed/23025485 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja306068g |
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