Chemical and Structural Analysis of an Antibody Folding Intermediate Trapped during Glycan Biosynthesis

[Image: see text] Human IgG Fc glycosylation modulates immunological effector functions such as antibody-dependent cellular cytotoxicity and phagocytosis. Engineering of Fc glycans therefore enables fine-tuning of the therapeutic properties of monoclonal antibodies. The N-linked glycans of Fc are ty...

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Main Authors: Bowden, Thomas A., Baruah, Kavitha, Coles, Charlotte H., Harvey, David J., Yu, Xiaojie, Song, Byeong-Doo, Stuart, David I., Aricescu, A. Radu, Scanlan, Christopher N., Jones, E. Yvonne, Crispin, Max
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2012
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3593610/
https://ncbi.nlm.nih.gov/pubmed/23025485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja306068g
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