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Investigation of the Possible Pharmacologically Active Forms of the Nicotinic Acetylcholine Receptor Agonist Anabaseine

Three major forms of the nicotinic agonist toxin anabaseine (cyclic iminium, cyclic imine and the monocationic open-chain ammonium-ketone) co-exist in almost equal concentrations at physiological pH. We asked the question: Which of these forms is pharmacologically active? First, we investigated the...

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Detaylı Bibliyografya
Yayımlandı:Mar Drugs
Asıl Yazarlar: Andrud, Kristin, Xing, Hong, Gabrielsen, Bjarne, Bloom, Linda, Mahnir, Vladimir, Lee, Stephen, Green, Benedict T., Lindstrom, Jon, Kem, William
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: MDPI 2019
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6891768/
https://ncbi.nlm.nih.gov/pubmed/31671780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md17110614
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