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Investigation of the Possible Pharmacologically Active Forms of the Nicotinic Acetylcholine Receptor Agonist Anabaseine

Three major forms of the nicotinic agonist toxin anabaseine (cyclic iminium, cyclic imine and the monocationic open-chain ammonium-ketone) co-exist in almost equal concentrations at physiological pH. We asked the question: Which of these forms is pharmacologically active? First, we investigated the...

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Bibliografiska uppgifter
I publikationen:Mar Drugs
Huvudupphovsmän: Andrud, Kristin, Xing, Hong, Gabrielsen, Bjarne, Bloom, Linda, Mahnir, Vladimir, Lee, Stephen, Green, Benedict T., Lindstrom, Jon, Kem, William
Materialtyp: Artigo
Språk:Inglês
Publicerad: MDPI 2019
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6891768/
https://ncbi.nlm.nih.gov/pubmed/31671780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md17110614
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