Bioactivation of napabucasin triggers reactive oxygen species–mediated cancer cell death

PURPOSE: Napabucasin (2-acetylfuro-1,4-naphthoquinone or BBI-608) is a small molecule currently being clinically evaluated in various cancer types. It has mostly been recognized for its ability to inhibit STAT3 signaling. However, based on its chemical structure, we hypothesized that napabucasin is...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Froeling, Fieke E M, Swamynathan, Manojit Mosur, Deschênes, Astrid, Chio, Iok In Christine, Brosnan, Erin, Yao, Melissa A, Alagesan, Priya, Lucito, Matthew, Li, Juying, Chang, An-Yun, Trotman, Lloyd C, Belleau, Pascal, Park, Youngkyu, Rogoff, Harry A, Watson, James D, Tuveson, David A
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6891204/
https://ncbi.nlm.nih.gov/pubmed/31527169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-0302
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