Exploiting arginine auxotrophy with pegylated arginine deiminase (ADI-PEG20) to sensitize pancreatic cancer to radiotherapy via metabolic dysregulation

Distinct metabolic vulnerabilities of cancer cells compared to normal cells can potentially be exploited for therapeutic targeting. Deficiency of argininosuccinate synthetase-1 (ASS1) in pancreatic cancers creates auxotrophy for the semi-essential amino acid arginine. We explored the therapeutic pot...

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Publicado en:Mol Cancer Ther
Autores principales: Singh, Pankaj K., Deorukhkar, Amit A., Venkatesulu, Bhanu P., Li, Xiaolin, Tailor, Ramesh, Bomalaski, John S., Krishnan, Sunil
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6891156/
https://ncbi.nlm.nih.gov/pubmed/31395686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-18-0708
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