Population pharmacokinetics of afatinib and exposure-safety relationships in Japanese patients with EGFR mutation-positive non-small cell lung cancer

To investigate the exposure–safety relationships of afatinib in Japanese population, we performed population pharmacokinetics (PK) analysis of afatinib in Japanese advanced non-small cell lung cancer patients harboring epidermal growth factor receptor mutation. Plasma samples were collected at 0.5–1...

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Publicado en:Sci Rep
Main Authors: Nakao, Keiko, Kobuchi, Shinji, Marutani, Shuhei, Iwazaki, Ayano, Tamiya, Akihiro, Isa, Shunichi, Okishio, Kyoichi, Kanazu, Masaki, Tamiya, Motohiro, Hirashima, Tomonori, Imai, Kimie, Sakaeda, Toshiyuki, Atagi, Shinji
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6890782/
https://ncbi.nlm.nih.gov/pubmed/31796841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-54804-9
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