The ratio of T790M to EGFR-activating mutation predicts response of osimertinib in 1st or 2nd generation EGFR-TKI-refractory NSCLC

The most frequent mechanism of resistance after 1st/2nd-generation (G) epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) is secondary point mutation Thr790Met (T790M) in EGFR. Afatinib followed by osimertinib (Afa group) may provide better outcomes for T790M-positive non-smal...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Tamiya, Motohiro, Tamiya, Akihiro, Okamoto, Norio, Taniguchi, Yoshihiko, Nishino, Kazumi, Atagi, Shinji, Hirashima, Tomonori, Imamura, Fumio, Kumagai, Toru, Suzuki, Hidekazu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8099906/
https://ncbi.nlm.nih.gov/pubmed/33953280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-89006-9
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