Prenatal Glucocorticoid Exposure Results in Changes in Gene Transcription and DNA Methylation in the Female Juvenile Guinea Pig Hippocampus Across Three Generations

Synthetic glucocorticoids (sGC) are administered to women at risk for pre-term delivery, to mature the fetal lung and decrease neonatal morbidity. sGC also profoundly affect the fetal brain. The hippocampus expresses high levels of glucocorticoid (GR) and mineralocorticoid receptor (MR), and its dev...

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Библиографические подробности
Опубликовано в: :Sci Rep
Главные авторы: Constantinof, Andrea, Boureau, Lisa, Moisiadis, Vasilis G., Kostaki, Alisa, Szyf, Moshe, Matthews, Stephen G.
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2019
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6890750/
https://ncbi.nlm.nih.gov/pubmed/31796763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-54456-9
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