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Activity of TAS4464, a novel NEDD8 activating enzyme E1 inhibitor, against multiple myeloma via inactivation of nuclear factor κB pathways

The ubiquitin proteasome pathway is essential for the proliferation and survival of multiple myeloma (MM) cells. TAS4464, a novel highly potent inhibitor of NEDD8 activating enzyme, selectively inactivates cullin‐RING ubiquitin E3 ligases, resulting in accumulation of their substrates. Here, we exam...

詳細記述

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書誌詳細
出版年:Cancer Sci
主要な著者: Muraoka, Hiromi, Yoshimura, Chihoko, Kawabata, Rumi, Tsuji, Shingo, Hashimoto, Akihiro, Ochiiwa, Hiroaki, Nakagawa, Fumio, Fujioka, Yayoi, Matsuo, Kenichi, Ohkubo, Shuichi
フォーマット: Artigo
言語:Inglês
出版事項: John Wiley and Sons Inc. 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6890451/
https://ncbi.nlm.nih.gov/pubmed/31583781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.14209
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