Palmitic Acid–Rich High-Fat Diet Exacerbates Experimental Pulmonary Fibrosis by Modulating Endoplasmic Reticulum Stress

The impact of lipotoxicity on the development of lung fibrosis is unclear. Saturated fatty acids, such as palmitic acid (PA), activate endoplasmic reticulum (ER) stress, a cellular stress response associated with the development of idiopathic pulmonary fibrosis (IPF). We tested the hypothesis that P...

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Vydáno v:Am J Respir Cell Mol Biol
Hlavní autoři: Chu, Sarah G., Villalba, Julian A., Liang, Xiaoliang, Xiong, Kevin, Tsoyi, Konstantin, Ith, Bonna, Ayaub, Ehab A., Tatituri, Raju V., Byers, Derek E., Hsu, Fong-Fu, El-Chemaly, Souheil, Kim, Edy Y., Shi, Yuanyuan, Rosas, Ivan O.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Thoracic Society 2019
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6890409/
https://ncbi.nlm.nih.gov/pubmed/31461627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2018-0324OC
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