Structural basis for the diversity of the mechanism of nucleotide hydrolysis by the aminoglycoside-2′′-phosphotransferases

Aminoglycoside phosphotransferases (APHs) are one of three families of aminoglycoside-modifying enzymes that confer high-level resistance to the aminoglycoside antibiotics via enzymatic modification. This has now rendered many clinically important drugs almost obsolete. The APHs specifically phospho...

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Xehetasun bibliografikoak
Argitaratua izan da:Acta Crystallogr D Struct Biol
Egile Nagusiak: Smith, Clyde A., Toth, Marta, Stewart, Nichole K., Maltz, Lauren, Vakulenko, Sergei B.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: International Union of Crystallography 2019
Gaiak:
Research Papers
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6889913/
https://ncbi.nlm.nih.gov/pubmed/31793906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2059798319015079
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