A Read/Write Mechanism Connects p300 Bromodomain Function to H2A.Z Acetylation

Acetylation of the histone variant H2A.Z (H2A.Zac) occurs at active regulatory regions associated with gene expression. Although the Tip60 complex is proposed to acetylate H2A.Z, functional studies suggest additional enzymes are involved. Here, we show that p300 acetylates H2A.Z at multiple lysines....

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Udgivet i:iScience
Main Authors: Colino-Sanguino, Yolanda, Cornett, Evan M., Moulder, David, Smith, Grady C., Hrit, Joel, Cordeiro-Spinetti, Eric, Vaughan, Robert M., Krajewski, Krzysztof, Rothbart, Scott B., Clark, Susan J., Valdés-Mora, Fátima
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6889796/
https://ncbi.nlm.nih.gov/pubmed/31727574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2019.10.053
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