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Potent reduction of plasma lipoprotein (a) with an antisense oligonucleotide in human subjects does not affect ex vivo fibrinolysis

It is postulated that lipoprotein (a) [Lp(a)] inhibits fibrinolysis, but this hypothesis has not been tested in humans due to the lack of specific Lp(a) lowering agents. Patients with elevated Lp(a) were randomized to antisense oligonucleotide [IONIS-APO(a)(Rx)] directed to apo(a) (n = 7) or placebo...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:J Lipid Res
मुख्य लेखकों: Boffa, Michael B., Marar, Tanya T., Yeang, Calvin, Viney, Nicholas J., Xia, Shuting, Witztum, Joseph L., Koschinsky, Marlys L., Tsimikas, Sotirios
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: The American Society for Biochemistry and Molecular Biology 2019
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6889713/
https://ncbi.nlm.nih.gov/pubmed/31551368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.P094763
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