Deciphering the Gene Regulatory Landscape Encoded in DNA Biophysical Features

Gene regulation in higher organisms involves a sophisticated interplay between genetic and epigenetic mechanisms. Despite advances, the logic in selective usage of certain genomic regions as regulatory elements remains unclear. Here we show that the inherent biophysical properties of the DNA encode...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:iScience
Main Authors: Pataskar, Abhijeet, Vanderlinden, Willem, Emmerig, Johannes, Singh, Aditi, Lipfert, Jan, Tiwari, Vijay K.
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6889597/
https://ncbi.nlm.nih.gov/pubmed/31731201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2019.10.055
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