Development of Lentiviral Vectors for HIV-1 Gene Therapy with Vif-Resistant APOBEC3G

Strategies to control HIV-1 replication without antiviral therapy are needed to achieve a functional cure. To exploit the innate antiviral function of restriction factor cytidine deaminase APOBEC3G (A3G), we developed self-activating lentiviral vectors that efficiently deliver HIV-1 Vif-resistant mu...

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Detalhes bibliográficos
Publicado no:Mol Ther Nucleic Acids
Main Authors: Delviks-Frankenberry, Krista A., Ackerman, Daniel, Timberlake, Nina D., Hamscher, Maria, Nikolaitchik, Olga A., Hu, Wei-Shau, Torbett, Bruce E., Pathak, Vinay K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6889484/
https://ncbi.nlm.nih.gov/pubmed/31778955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2019.10.024
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