Minimal Contribution of APOBEC3-Induced G-to-A Hypermutation to HIV-1 Recombination and Genetic Variation

Although the predominant effect of host restriction APOBEC3 proteins on HIV-1 infection is to block viral replication, they might inadvertently increase retroviral genetic variation by inducing G-to-A hypermutation. Numerous studies have disagreed on the contribution of hypermutation to viral geneti...

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Pubblicato in:PLoS Pathog
Autori principali: Delviks-Frankenberry, Krista A., Nikolaitchik, Olga A., Burdick, Ryan C., Gorelick, Robert J., Keele, Brandon F., Hu, Wei-Shau, Pathak, Vinay K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4871359/
https://ncbi.nlm.nih.gov/pubmed/27186986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005646
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