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Aberrations in Notch-Hedgehog signalling reveal cancer stem cells harbouring conserved oncogenic properties associated with hypoxia and immunoevasion

BACKGROUND: Cancer stem cells (CSCs) have innate abilities to resist even the harshest of therapies. To eradicate CSCs, parallels can be drawn from signalling modules that orchestrate pluripotency. Notch-Hedgehog hyperactivation are seen in CSCs, yet, not much is known about their conserved roles in...

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Publicat a:Br J Cancer
Autors principals: Chang, Wai Hoong, Lai, Alvina G.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6889439/
https://ncbi.nlm.nih.gov/pubmed/31523055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-019-0572-9
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