Intrastriatal injection of preformed alpha-synuclein fibrils alters central and peripheral immune cell profiles in non-transgenic mice

Parkinson’s disease (PD) is characterized by the accumulation of alpha-synuclein (α-syn) inclusions, the major component of Lewy bodies. Extracellular α-syn aggregates act as a damage-associated molecular pattern (DAMP) and the presence of autoantibodies against α-syn species in the cerebrospinal fl...

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Bibliographic Details
Published in:J Neuroinflammation
Main Authors: Earls, Rachael H., Menees, Kelly B., Chung, Jaegwon, Barber, James, Gutekunst, Claire-Anne, Hazim, Manuel G., Lee, Jae-Kyung
Format: Artigo
Language:Inglês
Published: BioMed Central 2019
Subjects:
Short Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6889316/
https://ncbi.nlm.nih.gov/pubmed/31796095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-019-1636-8
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