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C10ORF12 modulates PRC2 histone methyltransferase activity and H3K27me3 levels
The polycomb repressive complex 2 (PRC2) catalyzes the methylation of histone H3 on lysine 27 (H3K27) to generate trimethyl-H3K27 (H3K27me3) marks, thereby leading to a repressive chromatin state that inhibits gene expression. C10ORF12 was recently identified as a novel PRC2 interactor. Here, we sho...
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| Publicado en: | Acta Pharmacol Sin |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Springer Singapore
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6889301/ https://ncbi.nlm.nih.gov/pubmed/31186533 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41401-019-0247-3 |
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