Combined poly-ADP ribose polymerase and ataxia-telangiectasia mutated/Rad3-related inhibition targets ataxia-telangiectasia mutated-deficient lung cancer cells

BACKGROUND: Up to 40% of lung adenocarcinoma have been reported to lack ataxia-telangiectasia mutated (ATM) protein expression. We asked whether ATM-deficient lung cancer cell lines are sensitive to poly-ADP ribose polymerase (PARP) inhibitors and determined the mechanism of action of olaparib in AT...

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Pubblicato in:Br J Cancer
Autori principali: Jette, Nicholas R., Radhamani, Suraj, Arthur, Greydon, Ye, Ruiqiong, Goutam, Siddhartha, Bolyos, Anthony, Petersen, Lars F., Bose, Pinaki, Bebb, D. Gwyn, Lees-Miller, Susan P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6889280/
https://ncbi.nlm.nih.gov/pubmed/31481733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-019-0565-8
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