Myc controls a distinct transcriptional program in fetal thymic epithelial cells that determines thymus growth

Interactions between thymic epithelial cells (TEC) and developing thymocytes are essential for T cell development, but molecular insights on TEC and thymus homeostasis are still lacking. Here we identify distinct transcriptional programs of TEC that account for their age-specific properties, includi...

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Udgivet i:Nat Commun
Main Authors: Cowan, Jennifer E., Malin, Justin, Zhao, Yongge, Seedhom, Mina O., Harly, Christelle, Ohigashi, Izumi, Kelly, Michael, Takahama, Yousuke, Yewdell, Jonathan W., Cam, Maggie, Bhandoola, Avinash
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6889275/
https://ncbi.nlm.nih.gov/pubmed/31792212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13465-y
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