In silico chemical screening identifies epidermal growth factor receptor as a therapeutic target of drug-tolerant CD44v9-positive gastric cancer cells

BACKGROUND: Tumours consist of heterogeneous cancer cells and are likely to contain drug-tolerant cell subpopulations, causing early relapse. However, treatment strategies to eliminate these cells have not been established. METHODS: We established gastric cancer patient-derived cells (PDCs) to exami...

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Veröffentlicht in:Br J Cancer
Hauptverfasser: Mashima, Tetsuo, Iwasaki, Risa, Kawata, Naomi, Kawakami, Ryuhei, Kumagai, Koshi, Migita, Toshiro, Sano, Takeshi, Yamaguchi, Kensei, Seimiya, Hiroyuki
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6889183/
https://ncbi.nlm.nih.gov/pubmed/31607750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-019-0600-9
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