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GAC inhibitors with a 4-hydroxypiperidine spacer: Requirements for potency
Allosteric inhibitors of glutaminase (GAC), such as BPTES, CB-839 and UPGL00019, have great promise as inhibitors of cancer cell growth, but potent inhibitors with drug-like qualities have been difficult to achieve. Here, a small library of GAC inhibitors based on the UPGL00019 core is described. Th...
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| 出版年: | Bioorg Med Chem Lett |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6889173/ https://ncbi.nlm.nih.gov/pubmed/31474484 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2019.126632 |
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