Patient-derived organoids as a potential model to predict response to PD-1/PD-L1 checkpoint inhibitors

Selection of cancer patients for treatment with immune checkpoint inhibitors remains a challenge due to tumour heterogeneity and variable biomarker detection. PD-L1 expression in 24 surgical chordoma specimen was determined immunohistochemically with antibodies 28-8 and E1L3N. The ability of patient...

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Vydáno v:Br J Cancer
Hlavní autoři: Scognamiglio, Giosue, De Chiara, Annarosaria, Parafioriti, Antonina, Armiraglio, Elisabetta, Fazioli, Flavio, Gallo, Michele, Aversa, Laura, Camerlingo, Rosa, Cacciatore, Francesco, Colella, Gianluca, Pili, Roberto, de Nigris, Filomena
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
Témata:
Brief Communication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6889147/
https://ncbi.nlm.nih.gov/pubmed/31666667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-019-0616-1
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