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A novel inhibitor of MDM2 oncogene blocks metastasis of hepatocellular carcinoma and overcomes chemoresistance

Overexpression of the MDM2 oncogene and mutations in the p53 tumor suppressor commonly occur in hepatocellular carcinoma (HCC) and are associated with increased mortality due to this disease. Inhibiting MDM2 has been demonstrated to be a valid approach for the treatment of HCC. However, most of the...

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Bibliografski detalji
Izdano u:Genes Dis
Glavni autori: Wang, Wei, Hu, Bo, Qin, Jiang-Jiang, Cheng, Jian-Wen, Li, Xin, Rajaei, Mehrdad, Fan, Jia, Yang, Xin-Rong, Zhang, Ruiwen
Format: Artigo
Jezik:Inglês
Izdano: Chongqing Medical University 2019
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Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6889017/
https://ncbi.nlm.nih.gov/pubmed/31832522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gendis.2019.06.001
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