Creatine uptake regulates CD8 T cell antitumor immunity

T cells demand massive energy to combat cancer; however, the metabolic regulators controlling antitumor T cell immunity have just begun to be unveiled. When studying nutrient usage of tumor-infiltrating immune cells in mice, we detected a sharp increase of the expression of a CrT (Slc6a8) gene, whic...

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Publicat a:J Exp Med
Autors principals: Di Biase, Stefano, Ma, Xiaoya, Wang, Xi, Yu, Jiaji, Wang, Yu-Chen, Smith, Drake J., Zhou, Yang, Li, Zhe, Kim, Yu Jeong, Clarke, Nicole, To, Angela, Yang, Lili
Format: Artigo
Idioma:Inglês
Publicat: Rockefeller University Press 2019
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6888972/
https://ncbi.nlm.nih.gov/pubmed/31628186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20182044
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