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A novel gemcitabine derivative-loaded liposome with great pancreas-targeting ability

Gemcitabine (Gem) is a standard first-line treatment for pancreatic cancer (PC). However, its chemotherapeutic efficacy is hampered by various limitations such as short half-life, metabolic inactivation, and lack of tumor localizing. We previously synthesized a lipophilic Gem derivative (Gem formyl...

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Bibliografiske detaljer
Udgivet i:Acta Pharmacol Sin
Main Authors: Li, Pei-wen, Luo, Shi, Xiao, Lin-yu, Tian, Bo-le, Wang, Li, Zhang, Zhi-rong, Zeng, Ying-chun
Format: Artigo
Sprog:Inglês
Udgivet: Springer Singapore 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6888841/
https://ncbi.nlm.nih.gov/pubmed/31015736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41401-019-0227-7
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