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A Double Negative Feedback Loop between mTORC1 and AMPK Kinases Guarantees Precise Autophagy Induction upon Cellular Stress

Cellular homeostasis is controlled by an evolutionary conserved cellular digestive process called autophagy. This mechanism is tightly regulated by the two sensor elements called mTORC1 and AMPK. mTORC1 is one of the master regulators of proteostasis, while AMPK maintains cellular energy homeostasis...

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Podrobná bibliografie
Vydáno v:Int J Mol Sci
Hlavní autoři: Holczer, Marianna, Hajdú, Bence, Lőrincz, Tamás, Szarka, András, Bánhegyi, Gábor, Kapuy, Orsolya
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6888297/
https://ncbi.nlm.nih.gov/pubmed/31703252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20225543
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