Design and Synthesis of 4-(Heterocyclic Substituted Amino)-1H-Pyrazole-3-Carboxamide Derivatives and Their Potent Activity against Acute Myeloid Leukemia (AML)

Fms-like receptor tyrosine kinase 3 (FLT3) has been emerging as an attractive target for the treatment of acute myeloid leukemia (AML). By modifying the structure of FN-1501, a potent FLT3 inhibitor, 24 novel 1H-pyrazole-3-carboxamide derivatives were designed and synthesized. Compound 8t showed str...

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Vydáno v:Int J Mol Sci
Hlavní autoři: Zhi, Yanle, Wang, Zhijie, Yao, Chao, Li, Baoquan, Heng, Hao, Cai, Jiongheng, Xiang, Li, Wang, Yue, Lu, Tao, Lu, Shuai
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6887723/
https://ncbi.nlm.nih.gov/pubmed/31731727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20225739
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