Design and Synthesis of 4-(Heterocyclic Substituted Amino)-1<i>H</i>-Pyrazole-3-Carboxamide Derivatives and Their Potent Activity against Acute Myeloid Leukemia (AML)

Fms-like receptor tyrosine kinase 3 (FLT3) has been emerging as an attractive target for the treatment of acute myeloid leukemia (AML). By modifying the structure of FN-1501, a potent FLT3 inhibitor, 24 novel 1<i>H</i>-pyrazole-3-carboxamide derivatives were designed and synthesized. Com...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Yanle Zhi, Zhijie Wang, Chao Yao, Baoquan Li, Hao Heng, Jiongheng Cai, Li Xiang, Yue Wang, Tao Lu, Shuai Lu
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: MDPI AG 2019-11-01
Σειρά:International Journal of Molecular Sciences
Θέματα:
1<i>h</i>-pyrazole-3-carboxamide
aml
cyclin-dependent kinases
fms-like receptor tyrosine kinase 3
protein kinase inhibitors
anti-cancer
Διαθέσιμο Online:https://www.mdpi.com/1422-0067/20/22/5739
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