Fibroblast-specific plasminogen activator inhibitor-1 depletion ameliorates renal interstitial fibrosis after unilateral ureteral obstruction

BACKGROUND: Plasminogen activator inhibitor-1 (PAI-1) expression increases extracellular matrix deposition and contributes to interstitial fibrosis in the kidney after injury. While PAI-1 is ubiquitously expressed in the kidney, we hypothesized that interstitial fibrosis is strongly dependent on fib...

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Detalhes bibliográficos
Publicado no:Nephrol Dial Transplant
Main Authors: Yao, Lan, Wright, M Frances, Farmer, Brandon C, Peterson, Laura S, Khan, Amir M, Zhong, Jianyong, Gewin, Leslie, Hao, Chuan-Ming, Yang, Hai-Chun, Fogo, Agnes B
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
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ORIGINAL ARTICLES
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6887698/
https://ncbi.nlm.nih.gov/pubmed/31071225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ndt/gfz050
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