FHR4‐based immunoconjugates direct complement‐dependent cytotoxicity and phagocytosis towards HER2‐positive cancer cells

Directing selective complement activation towards tumour cells is an attractive strategy to promote their elimination. In the present work, we have generated heteromultimeric immunoconjugates that selectively activate the complement alternative pathway (AP) on tumour cells. We used the C4b‐binding p...

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Detalhes bibliográficos
Publicado no:Mol Oncol
Main Authors: Seguin‐Devaux, Carole, Plesseria, Jean‐Marc, Verschueren, Charlène, Masquelier, Cécile, Iserentant, Gilles, Fullana, Marie, Józsi, Mihály, Cohen, Jacques H. M., Dervillez, Xavier
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6887587/
https://ncbi.nlm.nih.gov/pubmed/31365168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12554
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