Interaction of the Factor H Family Proteins FHR-1 and FHR-5 With DNA and Dead Cells: Implications for the Regulation of Complement Activation and Opsonization

Complement plays an essential role in the opsonophagocytic clearance of apoptotic/necrotic cells. Dysregulation of this process may lead to inflammatory and autoimmune diseases. Factor H (FH), a major soluble complement inhibitor, binds to dead cells and inhibits excessive complement activation on t...

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Vydáno v:Front Immunol
Hlavní autoři: Kárpáti, Éva, Papp, Alexandra, Schneider, Andrea E., Hajnal, Dávid, Cserhalmi, Marcell, Csincsi, Ádám I., Uzonyi, Barbara, Józsi, Mihály
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7378360/
https://ncbi.nlm.nih.gov/pubmed/32765490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.01297
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