MiR‐195 and miR‐497 suppress tumorigenesis in lung cancer by inhibiting SMURF2‐induced TGF‐β receptor I ubiquitination

SMURF2 is a member of the HECT family of E3 ubiquitin ligases that have important roles as a negative regulator of transforming growth factor‐β (TGF‐β) signaling through ubiquitin‐mediated degradation of TGF‐β receptor I. However, the regulatory mechanism of SMURF2 is largely unknown. In this study,...

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Bibliografiske detaljer
Udgivet i:Mol Oncol
Main Authors: Chae, Dong‐Kyu, Park, Jinyoung, Cho, Moonsoo, Ban, Eunmi, Jang, Mihue, Yoo, Young Sook, Kim, Eunice EunKyeong, Baik, Ja‐Hyun, Song, Eun Joo
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2019
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6887584/
https://ncbi.nlm.nih.gov/pubmed/31581360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12581
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