A KLF4-DYRK2–mediated pathway regulating self-renewal in CML stem cells

Leukemia stem cells are a rare population with a primitive progenitor phenotype that can initiate, sustain, and recapitulate leukemia through a poorly understood mechanism of self-renewal. Here, we report that Krüppel-like factor 4 (KLF4) promotes disease progression in a murine model of chronic mye...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Park, Chun Shik, Lewis, Andrew H., Chen, Taylor J., Bridges, Cory S., Shen, Ye, Suppipat, Koramit, Puppi, Monica, Tomolonis, Julie A., Pang, Paul D., Mistretta, Toni-Ann, Ma, Leyuan, Green, Michael R., Rau, Rachel, Lacorazza, H. Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2019
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6887114/
https://ncbi.nlm.nih.gov/pubmed/31515251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2018875922
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