Intestinal IL-17R Signaling Constrains IL-18-Driven Liver Inflammation by the Regulation of Microbiome-Derived Products

Interleukin (IL)-17 signaling to the intestinal epithelium regulates the intestinal microbiome. Given the reported links between intestinal dysbiosis, bacterial translocation, and liver disease, we hypothesize that intestinal IL-17R signaling plays a critical role in mitigating hepatic inflammation....

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Pubblicato in:Cell Rep
Autori principali: Cruz, Patricia Castillo-dela, Wanek, Alanna G., Kumar, Pawan, An, Xiaojing, Elsegeiny, Waleed, Horne, William, Fitch, Adam, Burr, Ansen H.P., Gopalakrishna, Kathyayini P., Chen, Kong, Methé, Barbara A., Canna, Scott W., Hand, Timothy W., Kolls, Jay K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6886715/
https://ncbi.nlm.nih.gov/pubmed/31747600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.10.042
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