Intestinal IL-17R Signaling Constrains IL-18-Driven Liver Inflammation by the Regulation of Microbiome-Derived Products

Interleukin (IL)-17 signaling to the intestinal epithelium regulates the intestinal microbiome. Given the reported links between intestinal dysbiosis, bacterial translocation, and liver disease, we hypothesize that intestinal IL-17R signaling plays a critical role in mitigating hepatic inflammation....

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Cruz, Patricia Castillo-dela, Wanek, Alanna G., Kumar, Pawan, An, Xiaojing, Elsegeiny, Waleed, Horne, William, Fitch, Adam, Burr, Ansen H.P., Gopalakrishna, Kathyayini P., Chen, Kong, Methé, Barbara A., Canna, Scott W., Hand, Timothy W., Kolls, Jay K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6886715/
https://ncbi.nlm.nih.gov/pubmed/31747600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.10.042
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