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Accessibility of promoter DNA is not the primary determinant of chromatin-mediated gene regulation
DNA accessibility is thought to be of major importance in regulating gene expression. We test this hypothesis using a restriction enzyme as a probe of chromatin structure and as a proxy for transcription factors. We measured the digestion rate and the fraction of accessible DNA at almost all genomic...
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| Udgivet i: | Genome Res |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cold Spring Harbor Laboratory Press
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6886500/ https://ncbi.nlm.nih.gov/pubmed/31511305 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.249326.119 |
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