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Accessibility of promoter DNA is not the primary determinant of chromatin-mediated gene regulation

DNA accessibility is thought to be of major importance in regulating gene expression. We test this hypothesis using a restriction enzyme as a probe of chromatin structure and as a proxy for transcription factors. We measured the digestion rate and the fraction of accessible DNA at almost all genomic...

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Bibliografiska uppgifter
I publikationen:Genome Res
Huvudupphovsmän: Chereji, Răzvan V., Eriksson, Peter R., Ocampo, Josefina, Prajapati, Hemant K., Clark, David J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Cold Spring Harbor Laboratory Press 2019
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6886500/
https://ncbi.nlm.nih.gov/pubmed/31511305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.249326.119
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