Rare-variant pathogenicity triage and inclusion of synonymous variants improves analysis of disease associations of orphan G protein–coupled receptors

The pace of deorphanization of G protein–coupled receptors (GPCRs) has slowed, and new approaches are required. Small molecule targeting of orphan GPCRs can potentially be of clinical benefit even if the endogenous receptor ligand has not been identified. Many GPCRs lack common variants that lead to...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Dershem, Ridge, Metpally, Raghu P. R., Jeffreys, Kirk, Krishnamurthy, Sarathbabu, Smelser, Diane T., Hershfinkel, Michal, Carey, David J., Robishaw, Janet D., Breitwieser, Gerda E.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2019
Materias:
Molecular Bases of Disease
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6885620/
https://ncbi.nlm.nih.gov/pubmed/31628190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009253
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