Protein surface topography as a tool to enhance the selective activity of a potassium channel blocker

Tk-hefu is an artificial peptide designed based on the α-hairpinin scaffold, which selectively blocks voltage-gated potassium channels K(v)1.3. Here we present its spatial structure resolved by NMR spectroscopy and analyze its interaction with channels using computer modeling. We apply protein surfa...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Berkut, Antonina A., Chugunov, Anton O., Mineev, Konstantin S., Peigneur, Steve, Tabakmakher, Valentin M., Krylov, Nikolay A., Oparin, Peter B., Lihonosova, Alyona F., Novikova, Ekaterina V., Arseniev, Alexander S., Grishin, Eugene V., Tytgat, Jan, Efremov, Roman G., Vassilevski, Alexander A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Computational Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6885618/
https://ncbi.nlm.nih.gov/pubmed/31533989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010494
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