Modular Organization of α-Toxins from Scorpion Venom Mirrors Domain Structure of Their Targets, Sodium Channels

To gain success in the evolutionary “arms race,” venomous animals such as scorpions produce diverse neurotoxins selected to hit targets in the nervous system of prey. Scorpion α-toxins affect insect and/or mammalian voltage-gated sodium channels (Na(v)s) and thereby modify the excitability of muscle...

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Main Authors: Chugunov, Anton O., Koromyslova, Anna D., Berkut, Antonina A., Peigneur, Steve, Tytgat, Jan, Polyansky, Anton A., Pentkovsky, Vladimir M., Vassilevski, Alexander A., Grishin, Eugene V., Efremov, Roman G.
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2013
主題:
Computational Biology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3696675/
https://ncbi.nlm.nih.gov/pubmed/23637230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.431650
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