Modular Organization of α-Toxins from Scorpion Venom Mirrors Domain Structure of Their Targets, Sodium Channels

To gain success in the evolutionary “arms race,” venomous animals such as scorpions produce diverse neurotoxins selected to hit targets in the nervous system of prey. Scorpion α-toxins affect insect and/or mammalian voltage-gated sodium channels (Na(v)s) and thereby modify the excitability of muscle...

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Detalhes bibliográficos
Main Authors: Chugunov, Anton O., Koromyslova, Anna D., Berkut, Antonina A., Peigneur, Steve, Tytgat, Jan, Polyansky, Anton A., Pentkovsky, Vladimir M., Vassilevski, Alexander A., Grishin, Eugene V., Efremov, Roman G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Computational Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3696675/
https://ncbi.nlm.nih.gov/pubmed/23637230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.431650
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