Modular Organization of α-Toxins from Scorpion Venom Mirrors Domain Structure of Their Targets, Sodium Channels

To gain success in the evolutionary “arms race,” venomous animals such as scorpions produce diverse neurotoxins selected to hit targets in the nervous system of prey. Scorpion α-toxins affect insect and/or mammalian voltage-gated sodium channels (Na(v)s) and thereby modify the excitability of muscle...

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Bibliographic Details
Main Authors: Chugunov, Anton O., Koromyslova, Anna D., Berkut, Antonina A., Peigneur, Steve, Tytgat, Jan, Polyansky, Anton A., Pentkovsky, Vladimir M., Vassilevski, Alexander A., Grishin, Eugene V., Efremov, Roman G.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Computational Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3696675/
https://ncbi.nlm.nih.gov/pubmed/23637230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.431650
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