Tumor susceptibility gene 101 ameliorates endotoxin-induced cardiac dysfunction by enhancing Parkin-mediated mitophagy

Cardiac mitochondrial damage and subsequent inflammation are hallmarks of endotoxin-induced myocardial depression. Activation of the Parkin/PTEN-induced kinase 1 (PINK1) pathway has been shown to promote autophagy of damaged mitochondria (mitophagy) and to protect from endotoxin-induced cardiac dysf...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Essandoh, Kobina, Wang, Xiaohong, Huang, Wei, Deng, Shan, Gardner, George, Mu, Xingjiang, Li, Yutian, Kranias, Evangelia G., Wang, Yigang, Fan, Guo-Chang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6885607/
https://ncbi.nlm.nih.gov/pubmed/31619520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008925
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