Delayed Rectifier K(+)-Channel Is a Novel Therapeutic Target for Interstitial Renal Fibrosis in Rats with Unilateral Ureteral Obstruction

BACKGROUND: Delayed rectifier K(+)-channel, Kv1.3, is most predominantly expressed in T-lymphocytes and macrophages. In such leukocytes, Kv1.3-channels play pivotal roles in the activation and proliferation of cells, promoting cellular immunity. Since leukocyte-derived cytokines stimulate fibroblast...

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Udgivet i:Biomed Res Int
Main Authors: Abe, Nozomu, Toyama, Hiroaki, Saito, Kazutomo, Ejima, Yutaka, Yamauchi, Masanori, Mushiake, Hajime, Kazama, Itsuro
Format: Artigo
Sprog:Inglês
Udgivet: Hindawi 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6885154/
https://ncbi.nlm.nih.gov/pubmed/31828127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/7567638
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