Second-Generation Histamine H1 Receptor Antagonists Suppress Delayed Rectifier K(+)-Channel Currents in Murine Thymocytes

BACKGROUND/AIMS: Voltage-dependent potassium channels (Kv1.3) are predominantly expressed in lymphocyte plasma membranes. These channels are critical for the activation and proliferation of lymphocytes. Since second-generation antihistamines are lipophilic and exert immunomodulatory effects, they ar...

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Vydáno v:Biomed Res Int
Hlavní autoři: Saito, Kazutomo, Abe, Nozomu, Toyama, Hiroaki, Ejima, Yutaka, Yamauchi, Masanori, Mushiake, Hajime, Kazama, Itsuro
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi 2019
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6515180/
https://ncbi.nlm.nih.gov/pubmed/31183371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/6261951
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